Connect with us

uncategorized

This New Treatment May Effectively Prevent Onset of Autoimmune Diseases Such As Type 1 Diabetes

Published

on

Image Credit: Getty

The small protein that initially gained attention as an “exercise mimetic” now appears to play a significant role in immune regulation, according to the study’s authors.

A new study found that administering the small protein MOTS-c to type 1 diabetes-prone mice prevented the immune system from destroying insulin-producing pancreatic cells, effectively preventing the onset of the autoimmune disease.

Type 1 diabetes, formerly known as juvenile diabetes, is an autoimmune disease that affects between 5 percent and 10 percent of people with diabetes. In type 1 diabetes, the immune system attacks the pancreas’s islet regions, which are composed of hormone-producing cells.

When immune cells destroy healthy beta cells–pancreatic cells that produce the sugar-regulating hormone insulin–the body loses its ability to produce insulin, regulate blood sugar levels, and utilise sugar properly for energy.

The new study demonstrates how treating mice with MOTS-c promotes the activity of regulatory T cells–immune cells that recognise which cells are their own–and thus reduces the activation of “killer” T cells that attack healthy cells in the pancreatic islets.

In contrast, a subsequent analysis in humans revealed that type 1 diabetes patients had significantly lower MOTS-c levels in their blood than non-diabetic patients, and a study of human cells from both diabetic and non-diabetic patients revealed that MOTS-c treatment decreased “killer” T-cell activation.

MOTS-potential c’s immune-regulating function suggests new therapeutic targets for autoimmune diseases other than type 1 diabetes, says the study.

MOTS-c is one of several newly identified hormones encoded in the DNA of mitochondria, the “powerhouses” of cells that convert food to energy; the majority of other hormones are encoded in the nucleus’s DNA.

“The mitochondrial genome encodes for previously unknown genes that yield small proteins with multiple physiological roles, including aging, exercise, metabolism, and immunity,” the study author points out.

“Further studies on the molecular mechanism of these mitochondrial-encoded peptides are ongoing and may provide novel therapeutic targets for autoimmune conditions, which increases as we age.”

Image Credit: Getty

Read More

Article: revyuh.com

uncategorized

EE, Vodafone, Three and O2 warning: Millions of people sent dangerous scam texts and calls

Published

on

EE, Vodafone, Three and Virgin Media O2 customers have been put on red alert as tens of millions of people may have been bombarded with scam calls and text messages over the summer.

Original Source: express.co.uk

Continue Reading

uncategorized

Cheaper Fish Ready for Brexit Britain After Historic £21bn Deal With Norway and Iceland

Published

on

THE COST of your fish and chips could go down following the signing of a historic £21.6 billion deal with Norway, Iceland and Liechtenstein.

Source Here: express.co.uk

Continue Reading

Tech

Apple AirTag Review: Expensive, but Potentially Useful

Published

on

Apple’s new AirTag is a somewhat unique device, meant to help you keep track of personal objects by location on a map, and within short range. Is this Rs. 3,190 button-shaped device worth the fuss? Find out in this review.

Article: gadgets.ndtv.com

Continue Reading

Trending

EasyDailyNews.com